Medicinal Chemistry Core
The Medicinal Chemistry (MedChem) Core assists UT Health Science Center investigators in all aspects of small molecule drug development and research, including target validation, lead optimization, tool compound custom synthesis, small scale and multi-gram scale synthesis and purification, structural determination, and purity analysis.
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College of Pharmacy Building (881 Madison), Room 579
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Mon-Fri, 9:00am - 5:00pm
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Facilities
The core has 400 SF of synthetic chemistry laboratory, equipped with 33 SFof fume hoods, balances, heating mantles, stirrers, refrigerators, freezers, Buchi R-300 rotary evaporators with V-300 vacuum pumps, a lab oven, a Labconco Freezone 4.5 Liter lyophilizer, a Buchi Melting Point M-565, and a Reveleris PREP Purification System.
Services
- Target Validation and Drug Design
- Lead Optimization
- Small Molecule Custom Synthesis
- Scale-Up Synthesis and Purification
- Structural Determination by NMR, MS, Elemental Analysis, et al
- Consultation on any Issue about Chemistry and Chemicals
Core Director
Dr. Jiawang Liu, the core director, joined the UTHSC in September of 2017. He earned his BS in Pharmaceutical Science (2002) and his PhD in Medicinal Chemistry (2007) from Peking University Health Science Center, College of Pharmaceutical Science, Beijing, China. He has over 15 years of experience in drug design, synthesis, and screening, with 45 scientific papers published in the peer-reviewed journals.