| Angela Orr | College of Health Professions | Audiology & Speech Pathology - Hearing & Speech Center | Assistant Professor |
| Amila Orucevic | College of Medicine - Knoxville | Knox Pathology | Professor |
| Adepitan Owosho | College of Dentistry | Diagnostic Sciences & Oral Medicine | Associate Professor & Director |
| Mary Owens | College of Medicine - Memphis | Surgery - General Surgery | Assistant Professor |
| Dustin Osborne | College of Medicine - Knoxville | Knox Radiology | Professor |
| Henry Okafor | College of Medicine - Chattanooga | Chat Urology | Assistant Professor |
| Kyle Osborn | College of Medicine - Knoxville | Knox Family Medicine | Assistant Professor |
| Lucianne Olewinski | College of Medicine - Knoxville | Knox Family Medicine | Associate Professor |
| Marilyn Owens | College of Health Professions | Audiology & Speech Pathology - Hearing & Speech Center | Instructor |
| Peggy O'Cain | College of Medicine - Memphis | Family Medicine - WestTn Family Practice-Memphis | Assistant Professor |
| Shelley Ost | College of Medicine - Memphis | Medicine - Med General Internal Medicine | Associate Professor |
| Teresa O'Daniel | College of Dentistry | Dental Hygiene | Instructor |
| Twisha Oza | College of Medicine - Memphis | Pathology | Associate Professor |
| Ugochi Ogu | College of Medicine - Memphis | Medicine - Med Hematology | Associate Professor |